Evolutionary history of histone demethylase families: distinct evolutionary patterns suggest functional divergence |
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| Authors: | Xiaofan Zhou Hong Ma |
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| Institution: | (1) The Intercollege Graduate Program in Cell and Developmental Biology, the Huck Institutes of the Life Sciences, The Pennsylvania State University, 415 Life Science Building, 16802 University Park, Pennsylvania, USA;(2) Department of Biology, the Institute of Molecular Evolutionary Genetics, The Pennsylvania State University, 405D Life Science Building, 16802 University Park, Pennsylvania, USA;(3) School of Life Sciences, the Institute of Plant Biology, the Center for Evolutionary Biology, the Institutes of Biomedical Sciences, Fudan University, 200433 Shanghai, PR China |
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| Abstract: | Background Histone methylation can dramatically affect chromatin structure and gene expression and was considered irreversible until
recent discoveries of two families of histone demethylases, the KDM1 (previously LSD1) and JmjC domain-containing proteins.
These two types of proteins have different functional domains and distinct substrate specificities. Although more and more
KDM1 and JmjC proteins have been shown to have histone demethylase activity, our knowledge about their evolution history is
limited. |
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