Antibody-based approaches to diagnosis and characterization of oxidative phosphorylation diseases |
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| Authors: | Hanson B J Marusich M F Capaldi R A |
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| Affiliation: | Institute of Molecular Biology, University of Oregon, Eugene, OR 97403 1229, USA. |
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| Abstract: | ![]()
Mitochondrial disorders caused by defects in oxidative phosphorylation function are difficult to diagnose. Here we review the emerging use of antibody-based approaches for this diagnosis. Novel methods involving immunohistochemistry and immunocapture of defective enzymes for characterization are described that add to the arsenal of approaches available. |
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| Keywords: | Mitochondria Oxidative phosphorylation Monoclonal antibody |
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