<Emphasis Type="Italic">Msx1</Emphasis> and <Emphasis Type="Italic">Msx2</Emphasis>are required for endothelial-mesenchymal transformation of the atrioventricular cushions and patterning of the atrioventricular myocardium |
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| Authors: | Yi-Hui Chen Mamoru Ishii Henry M Sucov Jr" target="_blank">Robert E MaxsonJr |
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| Institution: | (1) Department of Biochemistry and Molecular Biology, USC/Norris Comprehensive Cancer Center and Hospital, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, 90089-9176 Los Angeles, CA, USA;(2) Institute for Genetic Medicine, Keck School of Medicine, University of Southern California, 2250 Alcazar Street, Suite 240, 90089-9075 Los Angeles, CA, USA;(3) Stem Cell Laboratories, Genomics Research Center, Acadmia Sinica, 11529 Taipei, Taiwan |
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| Abstract: | Background
Msx1 and Msx2, which belong to the highly conserved Nk family of homeobox genes, display overlapping expression patterns and redundant functions in multiple tissues and organs
during vertebrate development. Msx1 and Msx2 have well-documented roles in mediating epithelial-mesenchymal interactions during organogenesis. Given that both Msx1 and Msx2 are crucial downstream effectors of Bmp signaling, we investigated whether Msx1 and Msx2 are required for the Bmp-induced endothelial-mesenchymal transformation (EMT) during atrioventricular (AV) valve formation. |
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