神经元GPI锚定蛋白结构与功能研究进展

神经系统中的IgSF蛋白是一类重要的神经细胞表面分子,种类繁多,功能多样,其中一类分子缺乏跨膜区,通过GPI锚结合在细胞膜上,表现出结构和功能的特异性。本文对该类神经元GPI锚定蛋白分子作一系统介绍。根据结构特点,神经元GPI锚定蛋白分子可分为三类,各类分子通过Ig结构域与其自身或其它蛋白分子进行顺式或反式结合,调节神经细胞活动。

A Brief View on the Structure and Function Study of the Neuronal GPI-anchored Proteins

Neuronal IgSF(Ig superfamily)proteins play important roles in radial and tangential migration of neuronal precursors, neurite fasciculation,contact\|dependent axonal guidance and contact\|dependent inhibition of neurite growth.Among the neuronal IgSF,there is a subgroup of GPI\|linked proteins,which are lack of transmembrane domains.In the present review,we focus on the recent study on the classification,structure and their roles in growth cone guidance of the neural GPI\|linked proteins.;