| 以转录因子AP-1为靶的decoy核酸体内外抗肿瘤研究 |
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| 引用本文： | 王雪根,叶青,陈武领,冯莹,韦策,刘晖,欧阳平凯.以转录因子AP-1为靶的decoy核酸体内外抗肿瘤研究[J].生物化学与生物物理进展,2004,31(1):27-31. |
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| 作者姓名： | 王雪根 叶青 陈武领 冯莹 韦策 刘晖 欧阳平凯 |
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| 作者单位： | 1. 南京凯基生物科技发展有限公司,南京,210009
2. 南京工业大学制药与生命科学学院,南京,210009 |
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| 摘 要： | 合成了双链寡聚核苷酸——decoy核酸，其与靶转录因子AP-1有高亲和性，可进入细胞作为decoy顺式元件，通过抑制特异的转录因子和调控区域的结合，调控基因转录而改变基因的表达.在体内外抗肿瘤试验中, decoy核酸有显著抑制肿瘤细胞增殖的作用，可以成为潜在性的肿瘤基因治疗药物.
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| 关 键 词： | 转录因子AP-1，decoy核酸，转录调控，肿瘤 |
| 收稿时间： | 2003/5/22 0:00:00 |
| 修稿时间： | 2003/6/30 0:00:00 |
Antitumor Activity of Decoy Oligonucleotides Targeted to AP-1 In vitro and In vivo |
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| WANG Xue-Gen,YE Qing,CHEN Wu-Ling,FENG Ying,WEI Ce,LIU Hui and OUYANG Ping-Kai.Antitumor Activity of Decoy Oligonucleotides Targeted to AP-1 In vitro and In vivo[J].Progress In Biochemistry and Biophysics,2004,31(1):27-31. |
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| Authors: | WANG Xue-Gen YE Qing CHEN Wu-Ling FENG Ying WEI Ce LIU Hui and OUYANG Ping-Kai |
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| Institution: | Nanjing KeyGen Biotech. Inc., Nanjing 210002, China;Nanjing KeyGen Biotech. Inc., Nanjing 210002, China;Nanjing KeyGen Biotech. Inc., Nanjing 210002, China;Nanjing KeyGen Biotech. Inc., Nanjing 210002, China;Nanjing KeyGen Biotech. Inc., Nanjing 210002, China;Nanjing KeyGen Biotech. Inc., Nanjing 210002, China;College of Chemistry and Chemical Engineering, Nanjing University of Technology, Nanjing 210009,China |
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| Abstract: | Synthetic double-stranded oligonucleotides with high affinity for AP-1 transcrption factor can be introduced into cells as decoy cis-elements to bind the factor and alter gene expression by competition with AP-1 element.This decoy oligonucleotide restrained tumor cell proliferation in vitro and in vivo, and has important cancer gene therapeutic potential. |
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