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| 蝎氯毒素结构、功能与应用研究 | |
| 引用本文： | 许均华,吴英亮,罗锋,蒋达和. 蝎氯毒素结构、功能与应用研究[J]. 氨基酸和生物资源, 2005, 27(4): 13-16. DOI: 10.3969/j.issn.1006-8376.2005.04.005 |
| 作者姓名： | 许均华 吴英亮 罗锋 蒋达和 |
| 作者单位： | 武汉大学生命科学学院,武汉,430072;武汉大学生命科学学院,武汉,430072;武汉大学生命科学学院,武汉,430072;武汉大学生命科学学院,武汉,430072 |
| 基金项目： | 国家科技部重点攻关项目：2002BA49C |
| 摘 要： | 蝎氯毒素是一类能特异阻断神经胶质瘤氯电流的短链蝎毒素。它们具有高度的同源性、保守的基因序列与相似的3-D结构。根据其结构与功能的关系,推测它们可能有相似的药理功能。其中,Chlorotoxin(Cltx)能与神经胶质瘤细胞特异相互作用,并抑制其侵袭与转移。 |
| 关 键 词： | 氯离子通道蝎毒素 Chlorotoxin 神经胶质瘤 |
| 文章编号： | 1006-8376(2005)04-0013-04 |
| 收稿时间： | 2005-09-23 |
| 修稿时间： | 2005-09-23 |
Structural and Functional Relationship of Chloride Channel Scorpion Toxins and Advances in Application |
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| XU Jun-hua,WU Ying-liang,LUO Feng,JIANG Da-he. Structural and Functional Relationship of Chloride Channel Scorpion Toxins and Advances in Application[J]. Amino Acids & Biotic Resources, 2005, 27(4): 13-16. DOI: 10.3969/j.issn.1006-8376.2005.04.005 | |
| Authors: | XU Jun-hua WU Ying-liang LUO Feng JIANG Da-he |
| Affiliation: | College of Life Sciences, Wuhan University, Wuhan 430072, China |
| Abstract: | The scorpion chloride toxins are kinds of short chain scorpion toxins, which are able to block chloride currents on gliomas. They are in high homogeneity, extremely conserved in motif sequences and almost similar in 3-D structures. Based on the relationship of the structures and functions, they are probably the same in their pharmaceutical functions. Especially, Chlorotoxin(Cltx)is able to interact with glioma cells specially and therefore, inhibit their invation and migration. |
| Keywords: | scorpion chloride toxins chlorotoxin gliomas. |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |