Current scenario of COVID-19 in pediatric age group and physiology of immune and thymus response |
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| Institution: | 1. Department of Epidemic Disease Research, Institute of Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, 31441 Dammam, Saudi Arabia;2. Department of General Pediatric, Pediatrics and Children Hospital, Dammam, Saudi Arabia;3. Department of Public Health, College of Public Health, Imam Abdulrahman Bin Faisal University, 31441 Dammam, Saudi Arabia;4. Department of Genetic Disease Research, Institute of Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, 31441 Dammam, Saudi Arabia;5. Department of Biology, College of Science and Institute of Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, 31441 Dammam, Saudi Arabia |
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| Abstract: | COVID-19 pandemic caused by SARS-CoV-2, continues to manifest with severe acute respiratory syndrome among the adults, however, it offers a convincing indication of less severity and fatality in pediatric age group (0–18 years). The current trend suggests that children may get infected but are less symptomatic with less fatality, which is concordant to earlier epidemic outbreaks of SARS-CoV and MERS-CoV, in 2002 and 2012, respectively. According to the available data, children appear to be at lower risk for COVID-19, as adults constitute for maximum number of the confirmed cases (308,592) and deaths (13,069) as on 22nd March (https://www.worldometers.info/coronavirus). However, rapid publications and information of the adult patients with COVID-19 is in progress and published, on the contrary, almost no comprehensive data or discussion about the COVID-19 in children is available. Therefore, in this review, we outline the epidemiology, clinical symptoms, diagnosis, treatment, prevention, possible immune response and role of thymus in children to combat the COVID-19 outbreak. |
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| Keywords: | Children Coronaviruses COVID-19 Immunity Pandemic Thymus ARDS"} {"#name":"keyword" "$":{"id":"k0040"} "$$":[{"#name":"text" "_":"Acute Respiratory Distress Syndrome COVID-19"} {"#name":"keyword" "$":{"id":"k0050"} "$$":[{"#name":"text" "_":"Coronavirus Disease-2019 MERS-CoV"} {"#name":"keyword" "$":{"id":"k0060"} "$$":[{"#name":"text" "_":"Middle East Respiratory Syndrome Coronavirus pp1ab"} {"#name":"keyword" "$":{"id":"k0070"} "$$":[{"#name":"text" "_":"Polyprotein 1ab SARS-CoV"} {"#name":"keyword" "$":{"id":"k0080"} "$$":[{"#name":"text" "_":"Severe Acute Respiratory Syndrome Coronavirus WHO"} {"#name":"keyword" "$":{"id":"k0090"} "$$":[{"#name":"text" "_":"World Health Organization |
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