Algal biomass as a source for novel oral nano-antimicrobial agent |
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| Authors: | M. Vikneshan R. Saravanakumar R. Mangaiyarkarasi S. Rajeshkumar S.R. Samuel M. Suganya G. Baskar |
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| Affiliation: | 1. Dept of Public Health Dentistry, Indira Gandhi Institute of Dental Sciences, Sri Balaji Vidyapeeth University, Pondicherry, India;2. Dept of Periodontics, Indira Gandhi Institute of Dental Sciences, Sri Balaji Vidyapeeth University, Pondicherry, India;3. Central Inter-Disciplinary Research Facility, Sri Balaji Vidyapeeth University, Pondicherry, India;4. Dept of Pharmacology and Nanobiomedicine, Saveetha Dental College, SIMATS, Chennai 77, India;5. Dept of Public Health Dentistry, Saveetha Dental College and Hospital, Saveetha institute of Medical and Technical sciences, Chennai 77, India;6. Dept of Pedodontics and Preventive Dentistry, Indira Gandhi Institute of Dental Sciences, Sri Balaji Vidyapeeth University, Pondicherry, India;7. Department of Biotechnology, St. Joseph''s College of Engineering, Chennai 600119, India |
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| Abstract: | In the present study, sulphated polysaccharide Ulvan from Ulva lactuca was used for the synthesis of biogenic Selenium Nanoparticles (SeNPs) conjugate and Mouth rinse was prepared using this conjugate. The synthesis of nanoparticles was confirmed by UV–Visible spectrophotometry and characterized using Fourier transform infrared spectroscopy (FTIR), transmission electron microscope (TEM) and X-ray diffraction (XRD). TEM showed that the average size of the nanoparticle was 85 nm and spherical in shape. Furthermore, nanoparticle conjugates were evaluated for cell viability using MTT assay 3T3-L1 cell line and at 30 µl/ml showed 34% cell viability. The antimicrobial activity of SeNPs mouth rinse was tested against oral pathogens such as Streptococcus mutans, Staphylococcus aureus, Lactobacillus, and Candida albicans and it was effective against all tested microorganism at the concentration of 100 µl/ml. The present study has shown that Ulvan from algal biomass can be a safe and effective source for the development of oral nano-antimicrobial agents. |
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| Keywords: | Dental caries Nanoparticles Prevention mouth rinse Ulvan |
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