正常月经周期妇女卵泡液中激素水平的变化

本文测定了24例正常月经妇女在不同时相、不同大小卵泡的卵泡液中雌二醇(E_2)、孕酮(P_0)、雄烯二酮(A)、睾酮(T)、卵泡刺激素(FSH)、黄体生成素(LH)和催乳素(PRL)的含量,并分析其与外周血中相应激素浓度的关系。测定结果显示:小卵泡的卵泡液中E_2、Po,FSH,LH水平低于大卵泡中水平,而A和T水平则相反。排卵前大卵泡中E_2(9815nmol/L),P_0(3316nmol/L),FSH(1.34IU/L)和LH(3.9lIU/L)达最高值。A(280nmol/L)和T(137nmol/L)却较小卵泡中水平低(相应为692nmol/L和176nmol/L)。PRL水平在大小卵泡中无显著性差异。卵泡液中甾体激素水平高于外周血7—20.000倍,FSH、LH水平为外周血的10—80％,PRL水平为60％—3倍。

CHANGES OF HORMONE LEVELS IN FOLLICULAR FLUID IN WOMEN WITH NORMAL MENSTRUATION

Levels of estradiol (E2), progesterone (P0), androstenedione (A), testosterone (T), follicle stimulating hormone (FSH), luteinizing hormone (LH) and prolactin (PRL) in ovarian follicles of different sizes and at different phases of normal menstrual cycles were determined and, their relationships with those in peripheral blood were studied. According to the diameters, the follicles were divided into large (greater than 14 mm), median (8-14 mm) and small (less than 8 mm) ones. The results showed that the levels of E2, P0, FSH and LH were lower, whereas those of A and T were higher in small and median follicles, as compared with the large follicles. In the large follicles, particularly at the preovulatory phase, E2, P0, FSH and LH reached maximum levels. The concentration of E2 was 9815 nmol/L, P0, 3316 nmol/L, FSH 1.34 IU/L and LH 3.91 IU/L at the preovulatory phase. The concentrations of A and T were much lower in large follicles, being 280 nmol/L and 137 nmol/L respectively. No significant difference was found in PRL levels in follicles of different sizes. The steroid hormones in the follicular fluid were about 7-20,000 times higher than those in the peripheral blood, while FSH and LH were only about 10-80% and PRL was slightly higher than in peripheral blood.