Simian Y Chromosomes: species-specific rearrangements of DAZ, RBM, and TSPY versus contiguity of PAR and SRY |
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| Authors: | Birgitta Gläser Frank Grützner Ulrike Willmann Roscoe Stanyon Norbert Arnold Kay Taylor Wolfgang Rietschel Sylvia Zeitler Roland Toder Werner Schempp |
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| Institution: | (1) Institute of Human Genetics and Anthropology, University of Freiburg, Breisacher Str. 33, 79106 Freiburg, Germany, DE;(2) Institute of Physical Anthropology, University of Genoa, Via Balbi, 4/40p., 16126 Genova, Italy, IT;(3) Department of Gynecology, University of Kiel, Michaelisstr. 16, 24105 Kiel, DE;(4) The Galton Laboratory, University College London, Wolfson House, 4 Stephenson Way, London, NW1 2HE, UK, GB;(5) Zoologisch-Botanischer Garten Wilhelma, Postfach 501227, 70376 Stuttgart, Germany, DE |
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| Abstract: | The three human male specific expressed gene families DAZ, RBM, and TSPY are known to be repetitively clustered in the Y-specific
region of the human Y Chromosome (Chr). RBM and TSPY are Y-specifically conserved in simians, whereas DAZ cannot be detected on the Y chromosomes of New World monkeys. The proximity of SRY to the pseudoautosomal region (PAR) is highly conserved and thus most effectively stabilizes the pseudoautosomal boundary
on the Y (PABY) in simians. In contrast, the non-recombining part of the Y Chrs, including DAZ, RBM, and TSPY, was exposed to species-specific amplifications, diversifications, and rearrangements. Evolutionary fast fixation of any of
these variations was possible as long as they did not interfere with male fertility.
Received: 18 August 1997 / Accepted: 13 November 1997 |
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