Nuclear tumor suppressors in space and time |
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Authors: | Barbie David A Conlan Lindus A Kennedy Brian K |
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Affiliation: | Department of Internal Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. |
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Abstract: | Numerous studies have identified key binding partners and functional activities of nuclear tumor-suppressor proteins such as the retinoblastoma protein, p53 and BRCA1. Historically, less attention has been given to the subnuclear locations of these proteins. Here, we describe several recent studies that promote the view that regulated association with subcompartments of the nucleus is inherent to tumor-suppressor function. |
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