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Ischemia reperfusion dysfunction changes model-estimated kinetics of myofilament interaction due to inotropic drugs in isolated hearts |
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| Authors: | Samhita S Rhodes Amadou KS Camara Kristina M Ropella Said H Audi Matthias L Riess Paul S Pagel David F Stowe |
| Institution: | (1) Department of Anesthesiology, Medical College of Wisconsin, 8701 Watertown Plank Road, 53226 Milwaukee, WI, USA;(2) Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, 53226 Milwaukee, WI, USA;(3) Cardiovascular Research Center, Medical College of Wisconsin, 8701 Watertown Plank Road, 53226 Milwaukee, WI, USA;(4) Department of Pulmonary Medicine and Critical Care, Medical College of Wisconsin, 8701 Watertown Plank Road, 53226 Milwaukee, WI, USA;(5) Department of Biomedical Engineering, Marquette University, 1515 W Wisconsin Ave, 53233 Milwaukee, WI, USA;(6) VA Medical Center, 53295 Milwaukee, WI, USA |
| Abstract: | BackgroundThe phase-space relationship between simultaneously measured myoplasmic Ca2+] and isovolumetric left ventricular pressure (LVP) in guinea pig intact hearts is altered by ischemic and inotropic interventions. Our objective was to mathematically model this phase-space relationship between Ca2+] and LVP with a focus on the changes in cross-bridge kinetics and myofilament Ca2+ sensitivity responsible for alterations in Ca2+-contraction coupling due to inotropic drugs in the presence and absence of ischemia reperfusion (IR) injury. |
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