| 利用异源生物生产青蒿素及其前体的研究进展 |
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| 引用本文： | 李星,郝鹤,池剑亭,王红,叶和春.利用异源生物生产青蒿素及其前体的研究进展[J].植物学通报,2012(6):571-580. |
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| 作者姓名： | 李星 郝鹤 池剑亭 王红 叶和春 |
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| 作者单位： | [1]中国科学院大学生命科学学院,北京100049 [2]中国科学院植物研究所,北京100093 |
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| 基金项目： | 国家自然科学基金（No.61173098）; 中国科学院十二五基础前沿专项（No.KSCX2-EW-J-29） |
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| 摘 要： | 青蒿素是从中药青蒿中分离出来的一种倍半萜内酯类化合物,也是目前最有效的抗疟疾药物,对人类健康意义重大。该文通过对青蒿素生物合成途径及其相关酶的介绍,综述了利用异源生物通过组合生物合成途径生产青蒿素及其前体的最新研究进展。
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| 关 键 词： | 青蒿素 生物合成途径 大肠杆菌 恶性疟原虫 酵母 烟草 |
An Overview of Heterologous Organisms Used to Produce Artemisinin and Its Precursors |
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| Xing Li,He Hao,Jianting Chi,Hong Wang,Hechun Ye.An Overview of Heterologous Organisms Used to Produce Artemisinin and Its Precursors[J].Chinese Bulletin of Botany,2012(6):571-580. |
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| Authors: | Xing Li He Hao Jianting Chi Hong Wang Hechun Ye |
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| Institution: | 1College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China; 2Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China |
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| Abstract: | Artemisinin, a sesquiterpene endoperoxide lactone extracted from the traditional Chinese herb Artemisia annua, is an effective drug against the malaria parasite P/asmodium falciparum and has many positive effects on human health. We explored the possibility of producing artemisinin and its precursors by heterologous systems including Escherichia coli, Sacchromyces cerevisiae and tobacco. We also discuss recent progress in the artemisinin biosynthetic pathway and new genes and enzymes involved in artemisinin biosynthesis. |
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| Keywords: | artemisinin biosynthetic pathway Escherichia coli Plasmodium falciparum Sacchromyces cerevisiae tobacco |
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