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Glycosylated nordihydroguaiaretic acids as anti-cancer agents |
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| Authors: | Hwu Jih Ru Hsu Chuan-I Hsu Ming-Hua Liang Yu-Chuan Huang Ru Chih C Lee Yuan C |
| Affiliation: | a Department of Chemistry, National Tsing Hua University, Hsinchu 30013, Taiwan, ROC b Department of Chemistry, National Central University, Jhongli 32001, Taiwan, ROC c Department of Biology, The Johns Hopkins University, 3400 N. Charles Street, Baltimore, MD 21218, USA d Agricultural Biotechnology Research Center, Academia Sinica, Taipei 11529, Taiwan, ROC |
| Abstract: | Three perglycosylated nordihydroguaiaretic acids (NDGA) were synthesized through the Huiseng 1,3-dipolar cycloaddition reaction. These sugar-NDGA conjugates containing triazole-linkages possessed good solubility in water. NDGA-(triazol-galactose)4 (12b) and NDGA-(triazol-glucose)4 (12c) were found to act as inhibitors against human hepatocellular carcinoma Hep3B cells in culture. |
| Keywords: | Nordihydroguaiaretic acid NDGA Hepatocellular carcinoma Triazol-glucose Triazol-galactose |
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