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A new and efficient synthetic route for the anxiolytic agent CL285032 |
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| Authors: | Ghidu Victor P Ilies Marc A Cullen Tom Pollet Robert Abou-Gharbia Magid |
| Institution: | a Moulder Center for Drug Discovery Research, Temple University School of Pharmacy, 3307 N Broad Street, Philadelphia, PA 19140, USA b Department of Pharmaceutical Sciences, Temple University School of Pharmacy, 3307 N Broad Street, Philadelphia, PA 19140, USA c Fort Dodge Animal Health, 9 Deer Park Drive, Monmouth Junction, NJ 08852, USA |
| Abstract: | CL285032 is an anxiolytic compound currently under investigation as a possible treatment for canine noise phobia associated anxiety. A robust scale-up and manufacturing process is essential for the development and marketability of the drug. The current synthetic route, although reliable, requires seven steps and has a low overall yield (18%), leaving opportunity for improvement. We are presenting an efficient alternative approach toward the synthesis of CL285032 and the results thereof. |
| Keywords: | Triazolopyridazine synthesis Anxiolytic agent Noise phobia |
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