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Phospholipid methylation in MOPC-31C cell membranes with modified phospholipid composition |
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| Authors: | Masatomo Maeda Yasuhito Tanaka Yuzuru Akamatsu |
| Institution: | Department of Chemistry, National Institute of Health, Shinagawa-ku, Tokyo 141, Japan |
| Abstract: | The presence of the methylation pathway from phosphatidylethanolamine to phosphatidylcholine was first shown in MOPC-31C cells. Intermediate phospholipids of this pathway, phosphatidyl-N-monomethylethanolamine and phosphatidyl-N,N′-dimethylethanolamine, were accumulated in the cell membranes by adding choline analogues such as N-monomethylethanolamine and N,N′-dimethylethanolamine to the culture medium. These modified membranes had a striking character of enhanced phospholipid methylation. This enhancement could be explained by increases in the second and the third step of the methylation pathway from phosphatidylethanolamine. |
| Keywords: | TME trimethylethanolamine=choline DME N N′-dimethylethanolamine ME N-monomethylethanolamine E ethanolamine PE phosphatidylethanolamine PME phosphatidyl-N-monomethylethanolamine PDE phosphatidyl-N N′-dimethylethanolamine PC phosphatidylcholine MOPC mineral oil-induced plasmacytoma |
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