Actin-binding protein amplifies actomyosin contraction,and gelsolin confers calcium control on the direction of contraction |
| |
Authors: | Olle I Stendahl Thomas P Stossel |
| |
Institution: | 1. Hematology-Oncology Unit, Massachusetts General Hospital, Boston, Massachusetts 02114 USA;2. Department of Medicine, Harvard Medical School Boston, Massachusetts 02114 USA |
| |
Abstract: | Cross-linking of muscle actin filaments by low concentrations of actin-binding protein reduces the concentration of muscle myosin required for contraction of actin. Gelsolin, a macrophage protein that divides actin filaments in the presence of calcium, inhibits the amplifying effect of actin-binding protein on contraction of actomyosin. In a calcium gradient, the actomyosin gel moves from high to low calcium concentrations, indicating that calcium-controlled lattice formation can impart directionality to the movement of an isotropic actin network. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|