Formation of the cysteinyl form of slow reacting substance (leukotriene E4) in human plasma |
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| Authors: | Charles W. Parker Del Koch M.M. Huber S.F. Falkenhein |
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| Affiliation: | 1. Howard Hughes Medical Institute Laboratory Washington University School of Medicine St. Louis, Missouri 63110 USA;2. Department of Internal Medicine, Division of Allergy and Immunology Washington University School of Medicine St. Louis, Missouri 63110 USA |
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| Abstract: | ![]()
The two major species of slow reacting substance (SRS) contain either a glutathionyl or cysteinyl-glycyl side chain. Incubation of these SRS's with undiluted or diluted (usually 1:10 or 1:50) human plasma at 37°C resulted in marked losses of smooth muscle contracting activity due primarily to conversion of their oligopeptide side chains to cysteine. |
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| Keywords: | Address reprint requests to Dr. Parker. |
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