Hepatoprotective activity of betulonic acid amides containing piperidine or pyrrolidine nitroxide moieties |
| |
| Authors: | I. V. Sorokina D. S. Baev N. A. Zhukova T. G. Tolstikova A. N. Antimonova N. I. Petrenko E. E. Shults I. A. Grigor’ev |
| |
| Affiliation: | 1. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, pr. Lavrent’eva 9, Novosibirsk, 630090, Russia
|
| |
| Abstract: | ![]()
Betulonic acid amides containing the nitroxyl radical moiety exert an anticholestatic effect in mice. The introduction of piperidine nitroxide moiety into the lupane core increases its hepatoprotective activity. Oral administration of the piperidine nitroxide derivative in a dose of 50 mg/kg does not stimulate transplanted tumor growth and increases lifespan in mice. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
