Immunocytochemical observation of paraquat-induced alveolitis with special reference to class II MHC antigens |
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Authors: | Atsuo Nakayama Hiroshi Nagura Toyoharu Yokoi Masafumi Ito Junpei Asai |
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Institution: | 1. Department of Pathology, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, 466, Nagova, Japan 2. Department of Pathology, Tohoku University School of Medicine, 2-1 Seiryo-machi, Aoba-ku, 980, Sendai, Japan
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Abstract: | The expression of class II major histocompatibility complex (MHC) antigens on alveolar epithelial cells and macrophages was
investigated immunocytochemically in paraquat-induced alveolitis in the rat lung. Until 2 days after paraquat injection, class
II MHC antigens were expressed on the type II alveolar epithelium without any inflammatory cellular infiltration. From the
4th to the 7th day after paraquat injection, class II MHC antigen-positive macrophages increased in the alveolar spaces, whereas
the expression on the type II alveolar epithelium became obscure. Over 10 days after the injection, interstitial fibrosis
progressed and the intra-alveolar inflammatory infiltrates decreased. Epithelial cells lining the thickened fibrous septa
no longer expressed class II MHC antigens. These results suggest that chemical stimuli can induce class II MHC antigen expression
on the type II alveolar epithelium in the early stage of cellular injury, followed by inflammatory infiltration and interstitial
fibrosis. |
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Keywords: | Class II MHC antigens Immunohistochemistry Type II alveolar epithelium Paraquat alveolitis Pulmonary fibrosis |
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