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An Intermediate Pluripotent State Controlled by MicroRNAs Is Required for the Naive-to-Primed Stem Cell Transition
Authors:Peng Du  Mehdi Pirouz  Jiho Choi  Aaron J Huebner  Kendell Clement  Alexander Meissner  Konrad Hochedlinger  Richard I Gregory
Institution:1. Stem Cell Program, Division of Hematology/Oncology, Boston Children’s Hospital, Boston, MA 02115, USA;2. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA;3. Massachusetts General Hospital Department of Molecular Biology, Boston, MA 02114, USA;4. Massachusetts General Hospital Cancer Center and Center for Regenerative Medicine, Boston, MA 02114, USA;5. Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA;6. Harvard Stem Cell Institute, Cambridge, MA 02138, USA;7. Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA;8. Harvard Initiative for RNA Medicine, Boston, MA 02115, USA
Abstract:
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  • Keywords:embryonic stem cell  naive  primed  poised  pluripotency  miRNA  pro-miRNA  ISY1  embryoid body  EpiLC
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