| C-型钠尿肽与血管损伤性疾病 |
| |
| 作者姓名： | Chen JJ Qi YF Jiang ZS |
| |
| 作者单位： | 1. 南华大学医学院心血管研究所,湖南衡阳,421001
2. 北京大学医学部生理学与病理生理学系,北京,100083 |
| |
| 基金项目： | 教育部跨世纪优秀人才培养计划
,
国家自然科学基金 |
| |
| 摘 要： | C-型钠尿肽(C-type natriuretic peptide, CNP)作为钠尿肽家系的一员, 主要是由血管内皮分泌,CNP与血管平滑肌细胞钠尿肽受体-B(NPR-B)结合,激活颗粒型鸟苷酸环化酶,促进细胞内cGMP 水平升高,以旁分泌和/或自分泌方式调节循环系统功能稳态.CNP广泛分布于血管系统,尤其在内皮细胞中高表达.CNP具有利钠、利尿、调节血管张力、抑制血管平滑肌细胞迁移、增殖等作用,与高血压、动脉粥样硬化、血栓形成、冠脉成形术后再狭窄和血管钙化等多种血管损伤性疾病密切相关.
|
| 关 键 词： | 钠尿肽 血管损伤性疾病 血管钙化 钠尿肽 损伤性疾病 Vascular Diseases 相关 血管钙化 冠脉成形术后再狭窄 血栓形成 动脉粥样硬化 高血压 作用 增殖 血管平滑肌细胞迁移 血管张力 利尿 表达 内皮细胞 血管系统 分布 稳态 循环系统功能 |
C-type natriuretic peptide and injured vascular diseases |
| |
| Chen JJ,Qi YF,Jiang ZS.C-type natriuretic peptide and injured vascular diseases[J].Progress in Physiological Sciences,2008,39(2):119-123. |
| |
| Authors: | Chen Jing-Jing Qi Yong-Fen Jiang Zhi-Sheng |
| |
| Institution: | Institute of Cardiovascular Disease, Faculty of Medicine, University of South China, Hengyang 421001, China. |
| |
| Abstract: | C-type natriuretic peptide (CNP) is a member of Natriuretic peptides family which is synthesized and secreted by vascular endothelial cells. CNP can bind with specific G-protein coupling receptor -natriuretic peptide receptor-B (NPR-B) and elevate cellular cGMP level by activating guanylate cyclase. CNP regulates homeostasis of circulating system in an autocrine/paracrine manner. Vascular system, especially endothelium, is rich in CNP and its receptor. CNP exerts natruretic and natriuretic effect and regulates vessel tone, inhibits migration and proliferation of vascular smooth muscle cell. CNP is tightly correlated with injured vascular diseases such as hypertension, atherosclerosis, thrombogenesis, restenosis and vascular calcification. |
| |
| Keywords: | |
| 本文献已被 维普 万方数据 PubMed 等数据库收录！ |
|
