The nature of interactions responsible for the differences in the affinities of histones for DNA |
| |
| Authors: | V D Paponov P S Gromov N A Sokolov D M Spitkovsky P I Tseitlin |
| |
| Institution: | Institute of Medical Genetics, Kashirskoye shosse 6a, 115478, Moscow, USSR |
| |
| Abstract: | Electrophoretic studies on the sequential binding of histones to DNA and to polyphosphate in low ionic strength solution have shown that the affinities of histones for both the polyanions decreases in the same order: H4 ～ H3 > H2A > H2B>H1. This permits to suggest that hydrophobic DNA-histone interactions do not determine the relative affinity of histones for DNA. Non-ionic interactions within and between histone molecules participate in determining the histone affinity for DNA affecting electrostatic DNA-histone interactions. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
