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Glutamate-induced cell death in neuronal HT22 cells is attenuated by extracts from St. John's wort (Hypericum perforatum L.) |
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| Authors: | Anja Breyer Matthias Elstner Thomas Gillessen Dieter Weiser Erich Elstner |
| Affiliation: | Institute of Phytopathology, Laboratory of Applied Biochemistry, Technical University of Munich, Munich, Germany. |
| Abstract: | Glutamate-induced cell death of hippocampal HT22 cells is a model system for neuronal disorders due to depletion of glutathione levels and increase of intracellular reactive oxygen species. Standardized extracts of Hypericum perforatum (HPE) contain flavonoids known for antioxidative properties. In the above model, cytoprotective effects at a concentration of 0.05% HPE by attenuation of calcium fluxes and cellular energy statuses are reported. |
| Keywords: | Hypericum flavonoids Antioxidants Reactive oxygen Glutamate-induced cell death in neuronal HT22 cells Cytoprotective effects |
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