Aspects of early arthritis. Definition of disease states in early arthritis: remission versus minimal disease activity |
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Authors: | Annette HM van der Helm-van Mil Ferdinand C Breedveld Tom WJ Huizinga |
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Institution: | (1) Department of Rheumatology, Leiden University Medical Center, The Netherlands |
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Abstract: | With regard to rheumatoid arthritis, remission as currently used in the literature can have two meanings: either a state with
persistent absence of clinical and radiological signs of disease activity without being treated for a specific time period,
or it may point to a disease state with minimal disease activity during antirheumatic treatment. A risk factor for the first
is absence of autoantibodies, with the anti-CCP-antibodies as best predictors, whereas risk factors for achieving a drug-induced
state of minimal disease activity are not well defined. These definitions of remission refer to different disease states;
therefore, we propose that the term remission is reserved for patients that are not treated with antirheumatic drugs. |
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