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The Crystal Structure of the Active Form of the C-Terminal Kinase Domain of Mitogen- and Stress-Activated Protein Kinase 1
Authors:Margarita Malakhova  Igor D'Angelo  Hong-Gyum Kim  Ann M. Bode
Affiliation:1 The Hormel Institute University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA
2 Zymeworks, Inc., Vancouver, BC, Canada V6H 3V9
3 Cornell University, NE-CAT, Advanced Photon Source, Argonne, IL 60439, USA
Abstract:
Keywords:MSK1, mitogen- and stress-activated protein kinase 1   MAP, mitogen-activated protein   NTD MSK1, N-terminal kinase domain of MSK1   CTD MSK1, C-terminal kinase domain of mitogen- and stress-activated protein kinase 1   ERK, extracellular-signal-regulated kinase   CTD RSK2, C-terminal kinase domain of p90 ribosomal S6 kinase 2   MK2, MAP-kinase-activated protein kinase 2   SPR, surface plasmon resonance   EGF, epidermal growth factor   TPA, 12-O-tetradecanoyl-phorbol-13-acetate   APS, Advanced Photon Source   PDB, Protein Data Bank
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