Systemic Oxidative Stress Associated with the Neurological Diseases of Aging |
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| Authors: | Jorge A. Serra Raúl O. Domínguez Enrique R. Marschoff Eduardo M. Guareschi Arturo L. Famulari Alberto Boveris |
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| Affiliation: | 1.Free Radicals Program, Programa de Radicales Libres (PRALIB), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Oxidative Stress Laboratory, Faculty of Pharmacy and Biochemistry,University of Buenos Aires (UBA),Buenos Aires,Argentina;2.Faculty of Medicine, School of Neurology, Hospital Sirio-Libanés,University of Buenos Aires (UBA), Fundación Argentina Contra las Enfermedades Neurológicas del Envejecimiento (FACENE),Buenos Aires,Argentina;3.Faculty of Exacts and Natural Sciences, Biological Sciences Department, Laboratory of Biometry,University of Buenos Aires (UBA),Buenos Aires,Argentina;4.Laboratory for the Clinical Investigations (LEPLIC),Buenos Aires,Argentina;5.Faculty of Medicine, School of Neurology, Hospital Sirio-Libanés, Institute of Cardiology Research Prof. Dr. Alberto Taquini,University of Buenos Aires (UBA), Fundación Argentina Contra las Enfermedades Neurológicas del Envejecimiento (FACENE),Buenos Aires,Argentina |
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| Abstract: | Markers of oxidative stress were measured in blood samples of 338 subjects (965 observations): Alzheimer’s, vascular dementia, diabetes (type II) superimposed to dementias, Parkinson’s disease and controls. Patients showed increased thiobarbituric acid reactive substances (+21%; P < 0.05), copper-zinc superoxide dismutase (+64%; P < 0.001) and decreased antioxidant capacity (−28%; P < 0.001); pairs of variables resulted linearly related across groups (P < 0.001). Catalase and glutathione peroxidase, involved in discrimination between diseases, resulted non-significant. When diabetes is superimposed with dementias, changes resulted less marked but significant. Also, superoxide dismutase resulted not linearly correlated with any other variable or age-related (pure Alzheimer’s peaks at 70 years, P < 0.001). Systemic oxidative stress was significantly associated (P ≪ 0.001) with all diseases indicating a disbalance in peripheral/adaptive responses to oxidative disorders through different free radical metabolic pathways. While other changes—methionine cycle, insulin correlation—are also associated with dementias, the responses presented here show a simple linear relation between prooxidants and antioxidant defenses. |
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