Genetic control of contract hypersensitivity. II. Suppressor cells induced by intravenous injection of DNP-coupled syngeneic spleen cells possessing thy-1 antigen, I-J determinant, Lyt-2+, 3+ antigen, FcR- and DNP-membrane binding receptor on their surfaces

The characteristics of suppressor cells induced by 2,4-dinitrophenyl (DNP)-coupled syngeneic lymphocytes (syninduced suppressor cells) were studied. 2,4-dinitro-1-fluorobenzene (DNFB) contact hypersensitivity was completely suppressed when the syninduced suppressor cells were transferred intravenously. These syninduced suppressor cells had surface markers of Thy-1, FcR^? and Lyt-2⁺, 3⁺ antigens, as well as I-J gene products on their cell surfaces. The suppression of DNFB contact hypersensitivity was abrogated when these suppressor T cells were incubated in Petri dishes coated with the DNP-syngeneic lymphoid cell membrane, which suggests that these suppressor T cells had the specific antigen-binding receptors on their cell surfaces.