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The effect of taurine on the ion transport system in mitochondria |
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| Authors: | S V Murzaeva N V Belosludtseva L Gavrovskaya G D Mironova |
| Institution: | (1) Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, ul. Institutskaya 3, Pushchino, Moscow oblast, 142290, Russia;(2) Federal Institution Research Institute of Experimental Medicine, Russian Academy of Medical Sciences, ul. Akademika Pavlova 12, St.-Petersburg, 197376, Russia |
| Abstract: | The effect of taurine on the ATP-dependent mitochondrial swelling that characterizes the activity of mitochondrial ATP-dependent K+ channel and the formation of Ca2+-dependent pores, different in sensitivity to cyclosporin A, has been studied in rat liver mitochondria. It has been shown that taurine in micromolar concentrations (0.5–125 μM) stimulates the energy-dependent swelling of mitochondria. Taurine in physiological concentrations (0.5–20 mM) has no effect on the ATP-dependent swelling and the formation of cyclosporin A-insensitive Pal/Ca2+-activated pore in mitochondria. Taurine in these concentrations increased the rate of cyclosporin A-sensitive swelling of mitochondria induced by Ca2+ and Pi and reduced the Ca2+ capacity of mitochondria. The different effects of physiological taurine concentrations on the ATP-dependent transport of K+ and Ca2+ ions in mitochondrial membranes as compared with cell membranes are discussed. |
| Keywords: | mitochondria mito-KATP cyclosporin A-sensitive Ca2+-induced pore palmitate/Ca2+-activated pore cyclosporin A taurine |
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