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High yield regioselective monobenzyloxycarbonylation of secondary alcohols in glycopyranoside series |
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| Authors: | Morère Alain Mouffouk Fouzi Jeanjean Audrey Leydet Alain Montero Jean-Louis |
| Institution: | Laboratoire de Chimie Biomoléculaire (UMR 5032), Université Montpellier II-ENSCM, 8 Rue de l'Ecole Normale, F-3429 Montpellier, France. morere@univ-montp2.fr |
| Abstract: | The regioselective monobenzyloxycarbonylation of secondary alcohols in methyl 6-O-(4-methoxytrityl)-alpha-D-manno-, gluco- and galactopyranoside has been achieved in high yields (74-85%) by using benzyl chloroformate in the presence of 4-dimethylaminopyridine and/or 1,4-diazabicyclo2.2.2]octane. |
| Keywords: | Regioselectivity Protecting group Glycopyranoside series Benzyloxycarbonyl group |
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