Effect of sulphasalazine on the human intestinal flora |
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| Authors: | M.P. Hazenberg M. Barker H.C. Both-Patoir J.G.H. Ruseler van Embden A.M. Schroder |
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| Affiliation: | Department of Medical Microbiology, Erasmus University, Rotterdam, The Netherlands |
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| Abstract: | ![]()
Sulphasalazine is commonly used to treat patients with ulcerative colitis but the mode of action is still unexplained. To investigate a possible antibacterial effect of sulphasalazine, the faecal flora composition was studied in patients with ulcerative colitis and in mice harbouring a human intestinal flora. Patients on sulphasalazine were found to have an intestinal flora that was completely resistant to sulphapyri-dine. Oral administration of sulphasalazine did not influence the composition of the human flora in mice. |
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