Inhibition of gastric acid secretion in dogs by neurotensin |
| |
Authors: | Sven Andersson Ding Chang Karl Folkers Sune Rosell |
| |
Institution: | 1. Department of Pharmacology, Karolinska Institutet, 104 01 Stockholm 60, Sweden;2. Institute for Biochemical Research, The University of Texas at Austin, Austin, U.S.A. |
| |
Abstract: | Neurotensin is a tridacapeptide which has been isolated from bovine hypothalamus. The action of synthetic neurotensin was studied on gastric acid secretion in dogs provided with gastric pouches. Intravenously infused neurotensin, 50 ng × kg?1 × min?1, was found to produce a considerable inhibition of pentagastrin stimulated gastric acid secretion. On the other hand, there was no sign of inhibition of histamine induced gastric acid secretion. The experiments show that neurotensin, isolated from the central nervous system is a potent gastric secretory inhibitor and that it has a selective action in inhibiting gastric acid responses to pentagastrin but not to histamine. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|