Comparison of the pulmonary vascular response to prostaglandin A1, prostaglandin F2α and angiotensin II; Metabolism of PGA1 in lung |
| |
Authors: | Kenneth B Gross CN Gillis |
| |
Institution: | Departments of Anesthesiology and Pharmacology Yale University School of Medicine 333 Cedar Street New Haven, Connecticut 06510, USA |
| |
Abstract: | A rabbit lung preparation, perfused , was used to examine pulmonary metabolism of prostaglandin A1 (PGA1) and to compare the vasoconstrictor actions of PGA1, prostaglandin F2α (PGF2α) and angiotensin II. PGF2α caused significantly more, and angiotensin II significantly less, vasoconstriction than did an equimolar concentration of PGA1. Of three likely PGA1 metabolites only 15-keto-PGA1 had any significant vasoconstrictor action. Furosemide and aminophylline (10?3 M) reduced PGA1, PGF2α or angiotensin II-induced vasoconstruction. Diphloretin phosphate potentiated the vascular effect of angiotensin II. Furosemide (10?3 M) and DPP (9.5 × 10?6 M) significantly reduced pulmonary metabolism of PGA1 while aminophylline (10?3 M) had no effect on this process. Perfusion of the lungs with a hypoxic medium had no effect on PGA1 metabolism. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|