Comparative genomic analysis of <Emphasis Type="Italic">Lactobacillus plantarum</Emphasis> GB-LP4 and identification of evolutionarily divergent genes in high-osmolarity environment |
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Authors: | Jaehoon Jung Kwondo Kim DongAhn Yoo Chanho Lee Jungsun Kang Kyungjin Cho Dae-Kyung Kang Woori Kwak Sook Hee Yoon Hawsun Sohn Heebal Kim Seoae Cho |
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Institution: | 1.Department of Agricultural Biotechnology and Research Institute of Population Genomics,Seoul National University,Seoul,Republic of Korea;2.C&K Genomics,Seoul,Republic of Korea;3.Interdisciplinary Program in Bioinformatics,Seoul National University,Seoul,Republic of Korea;4.Genebiotech Co. Ltd.,Seoul,Republic of Korea;5.Department of Animal Resources Science,Dankook University,Cheonan,Republic of Korea;6.Cetacean Research Institute,National Institute of Fisheries Science,Ulsan,Republic of Korea |
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Abstract: | Lactobacillus plantarum is one of the widely-used probiotics and there have been a large number of advanced researches on the effectiveness of this species. However, the difference between previously reported plantarum strains, and the source of genomic variation among the strains were not clearly specified. In order to understand further on the molecular basis of L. plantarum on Korean traditional fermentation, we isolated the L. plantarum GB-LP4 from Korean fermented vegetable and conducted whole genome assembly. With comparative genomics approach, we identified the candidate genes that are expected to have undergone evolutionary acceleration. These genes have been reported to associate with the maintaining homeostasis, which are generally known to overcome instability in external environment including low pH or high osmotic pressure. Here, our results provide an evolutionary relationship between L. plantarum species and elucidate the candidate genes that play a pivotal role in evolutionary acceleration of GB-LP4 in high osmolarity environment. This study may provide guidance for further studies on L. plantarum. |
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