Caveolin‐1 as a promoter of tumour spreading: when,how, where and why |
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| Authors: | Rebecca Senetta Giulia Stella Ernesto Pozzi Niccolo Sturli Daniela Massi Paola Cassoni |
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| Affiliation: | 1. Department of Medical Sciences, University of Turin, , Turin, Italy;2. Department of Molecular Medicine, Section of Pneumology, Laboratory of Biochemistry & Genetics, University and Fondazione IRCCS Policlinico San Matteo, , Pavia, Italy;3. Policlinico di Monza and Department of Molecular Medicine, University of Pavia, , Monza, Italy;4. Department of Critical Care Medicine and Surgery, University of Florence, , Florence, Italy |
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| Abstract: | Caveolae are non‐clathrin invaginations of the plasma membrane in most cell types; they are involved in signalling functions and molecule trafficking, thus modulating several biological functions, including cell growth, apoptosis and angiogenesis. The major structural protein in caveolae is caveolin‐1, which is known to act as a key regulator in cancer onset and progression through its role as a tumour suppressor. Caveolin‐1 can also promote cell proliferation, survival and metastasis as well as chemo‐ and radioresistance. Here, we discuss recent findings and novel concepts that support a role for caveolin‐1 in cancer development and its distant spreading. We also address the potential application of caveolin‐1 in tumour therapy and diagnosis. |
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| Keywords: | caveolin‐1 cancer metastases biomarkers targeted therapy |
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