Comparative replication of natural,attenuated, and laboratory strains of mumps virus

Natural, Laboratory and attenuated strains of mumps virus replicate in similar fashion in chicken embryonic heart, lung and liver cells. Heart cells are maximally suceptible to all three strains of virus, and liver cells are the least susceptible. Infection of the immature chicken embryo results in the multiplication of both the natural and laboratory strain to highest titet in the heart near hatch. However, the attenuated Jeryl Lynn virus possesses limited capacity for persistent replication in chicken embryonic tissues.