Environmental factors, health-related habits, and serum selenium levels in cancer patients and healthy controls |
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Authors: | Dusan Backović Jelena Marinković Jagoda Jorga Milan Pavlica Zoran Maksimović Mihailo Nikolić |
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Institution: | (1) Institute of Hygiene and Medical Ecology, Pasteroua 2, 11000 Belgrade;(2) Institute of Statistics, School of Medicine, University of Belgrade, Yugoslavia;(3) Military Medical Academy, Belgrade, Yugoslavia;(4) Serbian Academy of Science and Arts, Belgrade |
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Abstract: | Previous studies conducted in Yugoslavia indicated that the concentration of selenium in soil, food items, and serum of the
population is very low. The aim of the study was to investigate the possible relationship among environmental, health-related
habits, nutrition, and selenium serum levels in cancer patients and the healthy population.
The case-control study included a group of cancer patients and a matched group of healthy controls: 57 cancer patients and
41 healthy controls living in Stari Grad (an urban area of Belgrade), as well as 17 cancer patients and 13 healthy controls
living in Barajevo (a rural community in the vicinity of Belgrade). The healthy controls were matched to cancer patients in
sex and age; they were not blood related.
The selenium serum levels were measured by atomic absorption spectrophotometry. Health-related habits and relevant dietary
factors (“food frequency” method) that may influence the selenium serum levels were assessed by questionnaires.
The differences in average values of selenium serum levels between the cancer patients and healthy controls were not significantly
different, but both were below the lowest recorded in referential studies. A significant difference between the values obtained
from urban and rural subgroups was noted.
The most important factors that influenced the level of selenium included the residence place in the region with selenium
deficiency (Barajevo), age, associated chronic diseases, and some dietary factors potentially related to the intake of selenium.
The results obtained in this investigation pointed out that use of selenium supplementation in this area should be seriously
considered.
Deceased |
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Keywords: | Selenium cancer patients dietary factors healthrelated habits |
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