Exocrine pancreatic secretion in response to a new CCK-analog, CCK33 and caerulein in dogs |
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| Authors: | C Beglinger T E Solomon K Gyr L Moroder E Wünsch |
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| Institution: | 1. Division of Gastroenterology, University Hospital, Basle, Switzerland;2. Research Service, Harry S. Truman Memorial VA Hospital U.S.A.;3. Department of Physiology, University of Missouri Medical School, Columbia, MO 65201, U.S.A.;4. Max Planck Institute, Munich, F.R.G. |
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| Abstract: | We studied the relative molar potencies of a newly synthetized cholecystokinin nonapeptide Thr28,Nle31]CCK25-33], natural porcine CCK33 and synthetic caerulein in conscious dogs with chronic gastric and pancreatic fistulas. Peptides were dissolved in albumin-containing solutions to prevent loss from solution. The three peptides were found to be equipotent on a molar basis in stimulating exocrine pancreatic secretion. As Thr28,Nle31]CCK9 is a peptide less susceptible to oxidation than other forms of CCK, it is an interesting analog with many uses for medical and biological research. |
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| Keywords: | pancreatic secretion CCK analogs relative potencies dog |
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