The Distribution of 35S-Sulfadiazine and 14G-Trimethoprim in Rainbow Trout,Salmo Gairdneri |
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| Authors: | Bergsjø Torill Nafstad Inger Ingebrigtsen Kristian |
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| Affiliation: | 1.Department of Pharmacology and Toxicology, Veterinary College of Norway, Dep., Oslo 1, P.O.Box 8146, Oslo, Norway
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| Abstract: | The distribution of 35S-labelled sulfadiazine and 14G-labelled trimethoprim was studied in rainbow trout by use of whole body autoradiography and liquid scintillation. As compared to mammals, gastrointestinal absorption and elimination were slow. Accumulation in the skin and the uveal tract of the eye was observed for both drugs tested. The results also indicated that the bile was an important route of excretion. Considerable radioactivity was still present in the skin at 144 hr. survival time. |
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