Glutamine synthetase (GS) expression is reduced in senile dementia of the Alzheimer type |
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Authors: | Ghislaine Le Prince Pia Delaere Christiane Fages Thierry Lefrançois Monique Touret Marcelle Salanon Marcienne Tardy |
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Institution: | (1) Inserm U 421, Faculté de Médecine, Hôpital Henri Mondor, 94010 Creteil cedex, France;(2) Laboratoire de Neuropathologie Raymond Escourolle, INSERM U 360, Association Claude Bernard, Hôpital de la Salpêtrière, bd de l'Hôpital, 75651 Paris cedex 13, France;(3) Department de Médecine Expérimentale, Université Claude Bernard, 8, avenue Rockefeller, 69373 Lyon cedex 08, France |
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Abstract: | Glutamine synthetase (GS), a metabolic marker of the mature astrocyte, was investigated in the temporal neocortex of postmortem brain samples of 8 cases, either not demented or affected by senile dementia of the Alzheimer type. A negative correlation between the GS protein level and the density of both classical A4 deposits and senile plaques was evidenced. Such a correlation for GS underlies a dysfunction of the astroglial metabolism and particularly of the glutamate and ammonia neutralization. Since GS is sensitive to oxidative lesioning, the changes in GS level that were observed, occurring at the posttranslational stage, might reflect oxidative damage and have severe consequences on the pathological cascade of events. |
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Keywords: | Blessed test score astrocyte classical senile plaque A4 classical deposits" target="_blank">gif" alt="beta" align="MIDDLE" BORDER="0">A4 classical deposits |
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