Stimulation by xanthine oxidase of 3T3 Swiss fibroblasts and human lymphocytes |
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| Authors: | F Stirpe T Higgins P L Tazzari E Rozengurt |
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| Affiliation: | Imperial Cancer Research Fund, Lincoln's Inn Fields, London, United Kingdom. |
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| Abstract: | Xanthine oxidase stimulates [3H]thymidine incorporation by 3T3 cells even in the absence of any added xanthine, but in the presence of, and synergistically with, insulin or various other growth-stimulating factors. Optimal stimulation was obtained with 2-3 mU enzyme/ml and higher concentrations were toxic. Xanthine oxidase also stimulated human peripheral blood lymphocytes in the presence of phytohemagglutinin and xanthine. |
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