1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholines: influence on aggregation and [3H]serotonin release of human thrombocytes |
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| Authors: | R Korth I Hillmar T Muramatsu N Zöllner |
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| Institution: | 1. Medical Clinic, University of München, Pettenkofer Str. 8a, D-8000 München 2 Germany;2. Federal Center for Lipid Research, Institute for Biochemistry and Technology - H.P. Kaufmann-Institute, Piusallee 68, D-4400 Münster Federal Republic of Germany |
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| Abstract: | 1-O-Alkyl-2-O-acetyl-sn-glycero-3-phosphocholines (platelet activating factor, PAF) aggregate human thrombocytes in a concentration dependent fashion. After a short lag-phase, maximum aggregation is reached within 2 min. PAF releases serotonin from human thrombocytes within 1 min. Indomethacin and creatine phosphate (CP)/creatine phosphokinase (CPK) are able to inhibit the second phase of the aggregation by PAF, while xylocain reduces both the first and second phase of aggregation of human thrombocytes. Hirudine neither influences the first nor the second phase of aggregation by PAF. |
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| Keywords: | alkylacetylglycerophosphocholines human thrombocytes aggregation serotonin release indomethacin creatine phosphate creatine phosphokinase xylocain hirudine |
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