The dsRNA ofTrichomonas vaginalis is associated with virus-like particles and does not correlate with metornidazole resistance |
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Authors: | J Flegr J ?erkasov J Kulda J Tachezy J ?tokrová |
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Institution: | (1) Faculty of Science, Charles University, 128 44 Prague 2;(2) Institute of Molecular Genetics, Czechoslovak Academy of Sciences, 166 37 Prague 6 |
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Abstract: | Twelve metronidazole-resistant and twelve metronidazole-susceptible strains ofTrichomonas vaginalis were tested for the presence of dsRNA. Three resistant and five susceptible strains were found to contain dsRNA which indicated
that metronidazole resistance does not correlate with the absence of dsRNA. Electron microscopy showed the homogenates of
all dsRNA -positive strains to contain virus-like particles 32 –38 nm in diameter, while no such particles were found in the
dsRNA-negative strains. A mutual relationship between the dsRNA and virus-like particles seems to exist.
After this paper had been accepted for publication the occurrence of virus-like particles in dsRNA-positive trichomonads was
reported by others (Wang A.L., Wang C.C.: The double stranded RNA inTrichomonas vaginalis may originate from virus-like particles.Proc. Nat. Acad. Sci. USA
83, 7956–7961, 1986). |
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