一氧化氮改变肾性高血压大鼠主动脉功能

探讨一氧化氮（ＮＯ）对二肾一夹（２Ｋ１Ｃ）肾性高血压大鼠主动脉功能的影响。实验分为５组：假手术、２Ｋ１Ｃ、卡托普利（ｃａｐｔｏｐｒｉｌ）、ＮＡＭＥ（Ｎω－Ｎｉｔｒｏ－Ｌ－ａｒｇｉｎｉｎｅ ｍｅｔｈｙｌ ｅｓｔｅｒ）和精氨酸组。结果显示：在２Ｋ１Ｃ组,大鼠手术后４周的平均动脉压显著升高,主动脉对４Ｃｈ的舒张反应明显减弱,对苯肾上腺素收缩反应明显增强,主动脉壁环鸟苷酸（ｃＧＭＰ）含量显著减少。卡托谱利

Nitric oxide changes aortic function in rats with renal hypertension

This work was undertaken to investigate the effect of nitric oxide (NO) on aortic function of two kidney and one clip (2K1C) rats with renal hypertension. Animals were divided into 5 groups: the sham operation, 2K1C, captopril, L arginine and L NAME groups. The results are as follows. At the 4th week after con~striction of the left renal artery, the mean arterial pressure was significantly elevated. In isolated aortic rings, acetylcholine induced dilation was attenuated, and phenylephrine induced contractile response was markedly enhanced. The level of aorta cGMP content was significantly lowered. These changes were abolished in 2K1C rats treated with captopril. L arginine partially reversed the aortic vascular reactivity of 2K1C rats, and elevated aortic cGMP content. In 2K1C rats treated with nitric oxide synthase inhibitor, L NAME, blood pressure was increased further, acetylcholine induced aorta diastolic response was attenuated further and cGMP content reduced, while phenylephrine induced contractile response was unaffected. These results suggest that deficiency of nitric oxide production and increase in renin angiotensin system activity may contribute to vascular endothelial dysfunction of 2K1C rats, and these factors may be involved in development and maintenance of 2K1C renal hypertension.