Rainbow trout p53: cDNA cloning and biochemical characterization. |
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| Authors: | C Caron de Fromentel F Pakdel A Chapus C Baney P May T Soussi |
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| Institution: | Unité d'Oncologie Moléculaire, IRSC, Villejuif, France. |
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| Abstract: | We have cloned and sequenced the p53-encoding cDNA of rainbow trout (Salmo gairdneri). The encoded product contains the characteristics found in all p53 proteins: (i) the five highly conserved domains, (ii) an acidic N terminus, (iii) a hydrophilic C terminus, and (iv) a penultimate serine residue. Furthermore, we demonstrate that the rainbow trout p53 is able to specifically interact with the SV40 large T antigen. |
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