Interleukin-22 protects rat PC12 pheochromocytoma cells from serum deprivation-induced cell death |
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Authors: | Yongchun Liu Wenyan Pan Shengmei Yang Xiaoying Wu Jianfu Wu Jun Ma Zengqiang Yuan Songshu Meng |
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Institution: | 1. Northern Jiangsu People’s Hospital, Nantong West Road No. 98, Yangzhou, 225001, China 4. Clinical Medical School, Yangzhou University, Yangzhou, 225001, China 2. College of Bioscience and Biotechnology, Yangzhou University, 48 Wenhuidong Road, Yangzhou, 225009, China 3. State Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China
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Abstract: | Interleukin-22 (IL-22), an IL-10 family cytokine, mediates the crosstalk between leukocytes and epithelial cells. Previous studies reported that IL-22 expresses in mouse brain, and the rat PC12 cells are responsive to IL-22 stimulation. However, the biological roles of IL-22 in neuronal cells remain largely unknown. We show here that IL-22 activates Stat3, p38 mitogen-activated protein kinases (MAPK), and Akt pathways and inhibits Erk/MAPK pathway in na?ve PC12 cells. We further demonstrate that IL-22 protects na?ve PC12 cells from serum starvation-induced cell death via the Jak1/Stat3 and Akt pathways. We also show that IL-22 has no effects on na?ve PC12 cell proliferation and cannot protect na?ve PC12 cells from 1-methyl-4-phenylpyridinium (MPP+)-induced cytotoxicity. However, IL-22 exerts a dose-dependent protective effect on MPP+-induced neurodegeneration in nerve growth factor-differentiated PC12 cells. Overall, our data suggest that IL-22 might play a role in neurological processes. To our knowledge, this is the first report showing that IL-22 confers a neuroprotective function, which may provide a new therapeutic option for treatment of neurodegenerative diseases. |
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