Relative stability of quadruplexes containing different number of G-tetrads |
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| Authors: | Petraccone Luigi Erra Eva Duro Ida Esposito Veronica Randazzo Antonio Mayol Luciano Mattia Carlo Andrea Barone Guido Giancola Concetta |
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| Affiliation: | Dipartimento di Scienze Farmaceutiche, Università di Salerno, Fisciano (SA), Italy. |
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| Abstract: | The aim of this work is to compare the physicochemical properties of three oligonucleotidic sequences, d(TGGGT), d(TGGGGT) and d(TGGGGGT), which assemble to form quadruplex structures with the same molecularity, but containing three, four, and five G-quartets, respectively. The addition of one or two G-tetrads greatly increases both the enthalpy and Tm values of the quadruplex dissociation. |
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