Function of caveolae in Ca2+ entry and Ca2+-dependent signal transduction |
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| Authors: | Isshiki Masashi Anderson Richard G W |
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| Affiliation: | Department of Nephrology and Endocrinology, University of Tokyo, Tokyo 113–8655, Japan;Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75235–9039, USA |
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| Abstract: | The correct spatial and temporal control of Ca2+ signaling is essential for such cellular activities as fertilization, secretion, motility, and cell division. There has been a long-standing interest in the role of caveolae in regulating intracellular Ca2+ concentration. In this review we provide an updated view of how caveolae may regulate both Ca2+ entry into cells and Ca2+-dependent signal transduction |
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| Keywords: | Ca2+ entry Ca2+ waves capacitative caveolae caveolin eNOS signal transduction store-operated Ca2+ entry |
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