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Incorporation of 8-histaminyl-deoxyadenosine [8-(2-(4-imidazolyl)ethylamino)-2'-deoxyriboadenosine] into oligodeoxyribonucleotides by solid phase phosphoramidite coupling
Authors:Lermer Leonard  Hobbs John  Perrin David M
Affiliation:Department of Chemistry, 2036 Main Mall, 6174 University Blvd, University of British Columbia, Vancouver, B. C., V6T-1Z1 Canada.
Abstract:The 3'phosphoramidite of 8-histaminyl deoxyadenosine has been prepared and successfully incorporated into a short oligodeoxyribonucleotide. The synthetic methodology leading to this preparation is given and the implications for developing new DNAzymes as well as probing unusual nucleic acid structures are discussed.
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