From nature to bedside: Pro-survival and cell death mechanisms as therapeutic targets in cancer treatment |
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| Authors: | Claudia Cerella,Marie-Hé lè ne Teiten,Flavia Radogna,Mario Dicato,Marc Diederich |
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| Affiliation: | 1. Laboratoire de Biologie Moléculaire et Cellulaire du Cancer, Hôpital Kirchberg, 9, rue Edward Steichen, L-2540 Luxembourg, Luxembourg;2. Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul 151-742, Republic of Korea |
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| Abstract: | ![]()
Cell death is an important physiological regulator during development, tissue homeostasis and stress response but it is also a protective tumor suppressive mechanism. Tumor cells almost universally acquire the ability to evade cell death pathways that in normal cells act as a protective mechanism to remove damaged cells. As a result, a population of death-resistant cells with accumulating genetic and epigenetic abnormalities contributes to malignant transformation. |
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| Keywords: | Apoptosis Necrosis Autophagy Reactive oxygen species |
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